I just bought the game. Installed the base game. Updated it. Played it. It saves and loads games fine.
OK. I had also bought the Eclipse expansion. Installed that, did all the updating.
Got back into the game, deleted my old save game (which was all of 2 turns, so it really didn't matter, it was just a test). Started a new game. Very nice. Played a few turns, saved the game. Ate lunch. Came back, launched game, hit load... and it gives me an "unknown error" that when I click it closes everything down.
So, I have a nice, expanded game that can't be played because it won't load any save game.
I uninstalled, redid everything incremently, confirmed that the base, updated game can save and load properly. The loading function only breaks when I install and update Eclipse. I do not have a way (I do not know of a way) to stop Eclipse from updating, so I don't know if the failed-load function is from the base Eclipse or the updates.
I deliberately held off on buying Pandora until an expansion came out that fleshed out the systems and made it much more interesting -- that would be Eclipse. So it's ironic that I can only currently play the base game and not the expansion.
So, what do I do now?
(yes, I updated all my drivers; and as I said, I reinstalled and checked each possible increment of play/update)