have you installed the game as admin?
right click on the install program and run as admin.
have you tried running the install in compatibility mode for the correct version of the game, if it's a windows xp aged game select that, if windows 7, select that etc
have you disabled you're anti virus while trying to install the game, gave the install program the admin and firewall rights? easy to check, just run the event viewer and it will log any errors, or your firewall and AV program.
have you installed all the pre requites that the game needs etc
please make sure all game pre requisite are installed with the game, even if you think or fully know there are already installed, it will only over write, and it may be that you have a older or newer version of these where as the game in question may need a certain version.
the correct version will be included with the game, no matter how old, they will be needed, even if you have a newer version installed...
next as you see if a game runs in 32bit, but you use a 64bit O/S like me, you still need to load both the 32/64 bit version as one file doesn't do both, same as the latest version of anything doesn't include the older versions either.
have you checked main to see if this game is windows 10 compatible? http://www.matrixgames.com/forums/tm.asp?m=3924215