Twilight Imperium - my favorite boardgame that I never have enough people to play. It may be a space game, but it has voting, special powers, colonization, ground and space combat, and THE BARONY OF LETNEV! ALL BOW BEFORE THE BARON! ...er... sorry about that...
I wouldn't mind seeing a computer gamer version of Arkham Horror, although it is not a wargame. In fact, I think it would make a pretty awesome PC conversion, as the players play against the board rather than themselves and the game is set up by getting event card then going to a location. It would work pretty well, I would think.
Agricola would be fun, but you would have to have actual human players, rather than AI. Might be easier as some sort of X-Box live thing that put players in automatically with no single player option.
I'm not a big fan of boardgames with radio manual type rules. I am a big fan of Diplomacy, so a GOOD PC conversion for this would be welcome...
"Neca eos omnes. Deus suos agnoscet!"
(Kill them all. God will know his own.)
-- Arnaud-Armaury, the Albigensian Crusade